Conclusive evidence that carbamazepine when given alone leads to congenital abnormalities or increases the risk of abnormalities is not available. In view of lack of adequate and rigorously controlled clinical trial data, carbamazepine should be prescribed if and only if the potential benefits outweigh the potential risks. Folic acid supplementation should always be given before and during pregnancy because carbamazepine aggravates its deficiency.
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